Journal article
Discriminating the earliest stages of mammary carcinoma using myoepithelial and proliferative markers
HM Duivenvoorden, A Spurling, SA O’Toole, BS Parker
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2018
Abstract
Mammographic screening has led to increased detection of breast cancer at a pre-invasive state, hence modelling the earliest stages of breast cancer invasion is important in defining candidate biomarkers to predict risk of relapse. Discrimination of pre-invasive from invasive lesions is critically important for such studies. Myoepithelial cells are the barrier between epithelial cells and the surrounding stroma in the breast ductal system. A number of myoepithelial immunohistochemistry markers have been identified and validated in human tissue for use by pathologists as diagnostic tools to distinguish in situ carcinoma from invasive breast cancer. However, robust myoepithelial markers for mo..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by grant funding from the National Health and Medical Research Council (NHMRC) (BSP 1047748 and 1127754) to BSP; fellowship support to BSP from Victorian Cancer Agency, SAOT from National Breast Cancer Foundation (Practitioner Fellowship PRAC-16-006) and HMD from Cancer Council Victoria. Support from the Sydney Breast Cancer Foundation is also gratefully acknowledged. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Clinical Labs provided support in the form of salaries for author SAOT, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the 'author contributions' section.